- Due to a glitch, Fire Fang penetrates Wonder Guard
- Pokemon with the ability Mold Breaker can disable abilities
- Pokemon with the ability Scrappy can penetrate Wonder Guard
- Pokemon with the move Gastro Acid can disable abilities
- Pokemon with either Odor Sleuth or Foresight can penetrate Wonder Guard
- Toxic, Poisoning and Burn statuses can slowly defeat Pokemon with Wonderguard (negated if they have Refresh)
- Sandstorm and Hail penetrate Wonder Guard defenses unless the pokemon in question resists those weathers naturally.
- Field affects such as Spikes, Toxic Spikes, Leech Seed and Stealth Rock can deal damage to Wonderguard users
- In total, the moves Beat Up, Bide, Doom Desire, Fire Fang, Future Sight, Hail, Leech Seed, Sandstorm, Spikes, Stealth Rock and Struggle all penetrate WonderGuard