Nah mate, and to be frank imo by that time because me and every millennial/player since gen 1 and even players since like bw will be old farts by then, wouldn't surprise me if Nintendo and even Gamefreak will have completely new and younger staff of that time and have gone through a complete overhaul like how they transitioned from playing cards all the way to video games and consoles in order to cater towards the new generations of kids at that point in time with whole new ways of gimmicky nonsense as Arthur said.
I'd say I'm more optimistic for as long as the current developers are around as they know what their old time fans want. I'll just enjoy the games so long as they are good and not something like f2p, cause in an expectation vs. reality scenario, I doubt the vast majority of current fans and even people on this here website and thread now will still be playing and hacking the games come that time, especially for the 100th anniversary. This is also assuming if no possible nuclear war bursts out by then.