I recently obtained a new Mac computer. My old one does not run OS X Mojave, but my current one does. On Yosemite, I don't have this issue, and I've just run PKHeX, and it went fine. This did not. I followed the OP instructions to the letter, including paying close attention to the prefix differences, as I did with my previous installations that were successful.
The hell do I do now?
Alright, this is a little bit, erm...roundabout so I'll see what I can explain.
1) You have your 32-bit prefix, I'll assume. You'll now need "wget". Type into Terminal the following code exactly: brew install wget.
2) Next, in order to get the winetrick for dotnet461 in the first place, type in:
3) Next, type in:
4) Follow installation instructions, then grab the other winetricks as instructed.
Hope this helps!