PPRE cause HGSS to freeze?

[neltazero]

I patched my heart gold and able to play it without freezing issue (at least for some time). Then, I load the patched rom with PPRE, and straight away write rom without changing anything, and it didn't cause any issue (although the rom size is reduced). Then, when I try to do something like changing the pokemon that appear at certain location (like make vulpix to appear instead of growlithe), after I write the rom and try it, it cause freezing issue (on the spot when apricot guy come out from his house to stop me).

Is editing wild pokemon encounter causing the game to freeze?

[aninymouse]

PPRE just can't edit certain routes AT ALL without causing crashes unless you get rid of the culprit scripts manually.